References

Metagen Enzyme is committed to the development of novel biocatalysts for industrial applications. This has been made possible by investigating the concepts and research technologies reported in the following peer-reviewed publications.

Adeola O. and Cowieson A.J. (2011). BOARD-INVITED REVIEW: opportunities and challenges in using exogenous enzymes to improve nonruminant animal production. Journal of Animal Science 89:3189-3218.

Fan M.Z. (2013). Swine Nutrition and Environment. In: Chiba L. (Ed.), Sustainable Swine Nutrition. John Wiley & Sons, Inc., pp. 365-411.

Forsberg, C.W., R.G. Meidinger, D. Murray, N.D. Keirstead, M.A. Hayes, M.Z. Fan, Jeyabarathy Ganeshapillai, M.A. Monteiro, S.P. Golovan, and J.P. Phillips. (2014). Phytase properties and locations in tissues of transgenic pigs secreting phytase in the saliva. Journal of Animal Science 92:3375-3387.

Goldberg R.F., Austen W.G., Zhang X., Munene G., Mostafa G., Biswas S., McCormack M., Eberlin K.R., Nguyen J.T., Tatlidede H.S., Warren H.S., Narisawa S., Millán J.L. and Hodin R.A. (2008). Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition. Proceedings of the National Academy of Sciences of the USA 105:3551-3556.

Golovan, S., R.D. Meidinger, A. Ajakaiye, M. Cottrill, M.Z. Weiderkehr, C. Plante, J. Pollard, M.Z. Fan, A. Hayes, A.C. Jesper Laursen, J.P. Hjorth, R.R. Hacker, D. Barney, J.P. Phillips and C. Forsberg. (2001). Enhanced phosphorus digestion and reduced pollution potential by pigs with salivary phytase. Nature Biotechnology 19:741-745.

Hess M., Sczyrba A., Egan R., Kim T.-W., Chokhawala H., Schroth G., Luo S., Clark D.S., Chen F. and Zhang T. (2011). Metagenomic discovery of biomass-degrading genes and genomes from cow rumen. Science 331:463-467.

Himmel M.E., Ding S.-Y., Johnson D.K., Adney W.S., Nimlos M.R., Brady J.W. and Foust T.D. (2007). Biomass recalcitrance: engineering plants and enzymes for biofuels production. Science 315:804-807.

Krause D.O., Denman S.E., Mackie R.I., Morrison M., Rae A.L., Attwood G.T. and McSweeney C.S. (2003). Opportunities to improve fiber degradation in the rumen: microbiology, ecology, and genomics. FEMS Microbiology Review 27:663-693.

Lackeyram D., Yang C., Archbold T., Swanson K.C. and Fan M.Z. (2010). Early weaning reduces small intestinal alkaline phosphatase expression in pigs. The Journal of Nutrition 140:461- 468.

Li J., Jia H., Cai X., Zhong H., Feng Q., Sunagawa S., Arumugam M., Kultima J.R., Prifti E., Nielsen T., Juncker A.S., Manichanh C., Chen B., Zhang W., Levenez F., Wang J., Xu X., Xiao L., Liang S., Zhang D. (2014). An integrated catalog of reference genes in the human gut microbiome. Nature Biotechnology 32:834-841.

Lynd L.R., Weimer P.J., Van Zyl W.H. and Pretorius I.S. (2002). Microbial cellulose utilization: fundamentals and biotechnology. Microbiology and Molecular Biology Reviews 66:506-577.

Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S., Plichta D.R., Gautier L., Pedersen A.G., Le Chatelier E., Pelletier E., Bonde I., Nielsen T., Manichanh C., Arumugam M., Batto J.M., Quintanilha Dos Santos M.B., Blom N., Borruel N., Burgdorf K.S. (2014). Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes. Nature Biotechnology 32:822-828.

Poelstra K., Bakker W.W., Klok P.A., Kamps J.A., Hardonk M.J. and Meijer D.K. (1997). Dephosphorylation of endotoxin by alkaline phosphatase in vivo. American Journal of Pathology 151:1163-1169.

Qin J., Li R., Raes J., Arumugam M., Burgdorf K.S., Manichanh C., Nielsen T., Pons N., Levenez F. and Yamada T. (2010). A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464:59-65.

Rideout T.C., Liu Q., Wood P. and Fan M.Z. (2008). Nutrient utilisation and intestinal fermentation are differentially affected by the consumption of resistant starch varieties and conventional fibres in pigs. British Journal of Nutrition 99:984-992.

Robin E.M. (2008). Genomics of cellulosic ethanol. Nature 454:841-845.

Shen Y., Y.L. Yin, E.R. Chavez and M.Z. Fan. (2005). Methodological aspects of measuring phytase activity and phytate phosphorus content in selected cereal grains and digesta and feces of pigs. Journal of Agricultural and Food Chemistry 53:853-859.

Sonnenburg J.L., Xu J., Leip D.D., Chen C.-H., Westover B.P., Weatherford J., Buhler J.D. and Gordon J.I. (2005). Glycan foraging in vivo by an intestine-adapted bacterial symbiont. Science 307:1955-1959.

Wang W., Archbold T., Kimber M.S., Li J., Lam J.S. and Fan M.Z. (2012). The porcine gut microbial metagenomic library for mining novel cellulases established from growing pigs fed cellulose-supplemented high-fat diets. Journal of Animal Science 90:400-402.

Wilson D.B. (2011). Microbial diversity of cellulose hydrolysis. Current Opinion of Microbiology 14:259-263.